TEAM-BY-TEAM 2006 INTERLEAGUE PLAY STATISTICS:
| American League | W-L | BA | HR | RUNS | ERA |
| Baltimore Orioles | 9-9 | .280 | 14 | 76 | 4.33 |
| Boston Red Sox | 12-6 | .315 | 32 | 126 | 3.79 |
| Chicago White Sox | 14-4 | .321 | 34 | 140 | 4.47 |
| Cleveland Indians | 8-10 | .267 | 21 | 85 | 4.44 |
| Detroit Tigers | 15-3 | .295 | 27 | 112 | 3.33 |
| Kansas City Royals | 10-8 | .287 | 17 | 110 | 5.48 |
| L.A. Angeles of Anaheim | 7-11 | .244 | 16 | 72 | 4.84 |
| Minnesota Twins | 16-2 | .302 | 19 | 123 | 2.74 |
| New York Yankees | 10-8 | .283 | 19 | 88 | 4.20 |
| Oakland Athletics | 8-10 | .213 | 6 | 58 | 3.80 |
| Seattle Mariners | 14-4 | .301 | 33 | 114 | 3.75 |
| Tampa Bay Devil Rays | 11-7 | .292 | 24 | 84 | 3.45 |
| Texas Rangers | 7-11 | .273 | 10 | 71 | 4.76 |
| Toronto Blue Jays | 9-9 | .288 | 17 | 77 | 4.21 |
| Totals | 154-98 | .283 | 289 | 1,336 | 4.11 |
| National League | W-L | BA | HR | RUNS | ERA |
| Arizona Diamondbacks | 4-11 | .256 | 12 | 65 | 6.02 |
| Atlanta Braves | 5-10 | .255 | 12 | 60 | 4.06 |
| Chicago Cubs | 4-11 | .279 | 20 | 66 | 6.87 |
| Cincinnati Reds | 6-9 | .262 | 27 | 73 | 5.72 |
| Colorado Rockies | 11-4 | .283 | 13 | 88 | 2.96 |
| Florida Marlins | 9-9 | .257 | 17 | 77 | 3.18 |
| Houston Astros | 7-11 | .246 | 14 | 75 | 4.49 |
| Los Angeles Dodgers | 5-10 | .283 | 9 | 68 | 4.78 |
| Milwaukee Brewers | 6-9 | .251 | 12 | 58 | 5.88 |
| New York Mets | 6-9 | .238 | 22 | 69 | 5.15 |
| Philadelphia Phillies | 5-13 | .258 | 22 | 81 | 6.02 |
| Pittsburgh Pirates | 3-12 | .269 | 15 | 71 | 5.47 |
| St. Louis Cardinals | 5-10 | .289 | 18 | 77 | 7.07 |
| San Diego Padres | 7-8 | .264 | 23 | 68 | 4.37 |
| San Francisco Giants | 8-7 | .237 | 12 | 51 | 3.55 |
| Washington Nationals | 7-11 | .246 | 13 | 68 | 5.49 |
| Totals | 98-154 | .261 | 261 | 1,115 | 5.04 |
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