As it stands, the slugger leads in all three Triple Crown categories -- batting average (.331), home runs (44) and RBIs (139) -- and by the time the first pitch is thrown at 8:10 ET, Cabrera should know where he stands.
Texas' Josh Hamilton, who is one behind Cabrera with 43 homers, will have concluded his regular season. And Angels rookie Mike Trout, barely in striking distance with a .325 batting average, will be deep into his final game as well.
So all eyes in the baseball community will be on Cabrera and if he can accomplish something that hasn't been done in 45 years.
Fortunately for the 29-year-old, he is 15-for-34 (.441) at Kauffman Stadium this year. And he has a good track record against Royals starter Luis Mendoza as well -- he's 4-for-11 (.364) with a home run.
"I'm feeling good," Cabrera said after Monday's 6-3 victory in KC. "There a lot of things, a lot of speculation, a lot of talk. ... I'm going to be the guy to go out there and try to win games. Right now, we're excited because we're winning."
Although they're set at the plate, Detroit had a dilemma on the mound but resolved it hours before game time. Right-hander Max Scherzer had been scratched from the scheduled start. After throwing a bullpen session on Monday in an attempt to recover from a right deltoid strain, he injured his right ankle during Monday's division-clinching celebration. But he was deemed healthy enough to face the Royals.
The Tigers were planning to give right-hander Luis Marte his first Major League start.
Tigers: Leyland talks postseason pitching
Leyland gave no definitive answer on how the starting rotation will look in the postseason. However, he did give a hint on Tuesday.
"You feel pretty comfortable as a manager if you can run, in any order you want, [Justin] Verlander, [Max] Scherzer, [Doug] Fister and [Anibal] Sanchez," he said. "That's pretty good."
The name not mentioned is Rick Porcello, who has struggled this season (10-12 with a 4.59 ERA). However, Porcello threw a five strong innings of four-hit, one-run ball to help the Tigers clinch the AL Central on Monday, which he was encouraged by.
"I just went up there and threw everything I had. It worked out. I'm just really happy we got the win," Porcello said.
Leyland did say the Tigers would carry eight bullpen arms. So although he might not be a starter, Porcello has a good shot at making the postseason roster.
Royals: Mendoza's results mixed vs. Tigers
Mendoza has had two starts with completely different results against the Tigers this season. In his first outing vs. Detroit on Aug. 28, he threw five innings and allowed six earned runs. His second time around, his last start on Thursday, he yielded two earned runs in seven innings. It's perhaps a deceiving 6.00 ERA.
For the first time since undergoing Tommy John surgery earlier this year, Royals closer Joakim Soria threw a baseball on Tuesday. He tossed it 25 times from 45. The Royals must decide in the offseason whether to take on Soria's $8 million option for 2013.
As Cabrera fights for the Triple Crown, he has another fan in Royals manager Ned Yost. The Royals are certainly trying to win the season finale, but would love to see history made in Kansas City.
"It would be a phenomenal thing if Miguel Cabrera could do it," Yost said on Tuesday.
If Cabrera ends the season tied in any category, it still counts as the Triple Crown. Yastrzemski matched Minnesota's Harmon Killebrew with 44 homers during his magical run in '67.